Journal
CONNECTIVE TISSUE RESEARCH
Volume 44, Issue -, Pages 298-299Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/03008200390181807
Keywords
eruption; MT1-MMP; periodontal ligament; root growth
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Funding
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [ZIADE000676] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [Z01DE000676] Funding Source: NIH RePORTER
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To study whether eruption of teeth and root growth require remodeling of collagen in the peridental tissues, we studied molar development in mice deficient in MT1-MMP, an enzyme essential for remodeling of soft tissue-hard tissue interfaces. The lower jaws of deficient mice and their wildtype littermates were subjected to stereologic analysis. It was shown that in deficient animals, eruption and root elongation were severely inhibited, signifying a role of the enzyme in these developmental processes.
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