Journal
CELL STEM CELL
Volume 13, Issue 3, Pages 270-283Publisher
CELL PRESS
DOI: 10.1016/j.stem.2013.08.002
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Funding
- National Institutes of Health
- California Institute for Regenerative Medicine
- Gladstone Institutes
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Small molecules that modulate stem cell fate and function offer significant opportunities that will allow the full realization of the therapeutic potential of stem cells. Rational design and screening for small molecules have identified useful compounds to probe fundamental mechanisms of stem cell self-renewal, differentiation, and reprogramming and have facilitated the development of cell-based therapies and therapeutic drugs targeting endogenous stem and progenitor cells for repair and regeneration. Here, we will discuss recent scientific and therapeutic progress, as well as new perspectives and future challenges for using chemical approaches in stem cell biology and regenerative medicine.
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