Journal
CELL STEM CELL
Volume 10, Issue 6, Pages 690-697Publisher
CELL PRESS
DOI: 10.1016/j.stem.2012.05.006
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Funding
- Terry Fox Run
- Stem Cell Network
- Canadian Institutes of Health Research (CIHR)
- Michael Smith Foundation for Health Research
- Kay Kendall Leukemia Fund Intermediate Fellowship from the UK
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Over the past 10 years, increasing evidence has accumulated that heterogeneity is a feature of hematopoietic stem cell (HSC) proliferation, self-renewal, and differentiation based on examination of these properties at a clonal level. The heterogeneous behavior of HSCs reflects the operation of a complex interplay of intrinsic and extrinsic variables. In this review, we discuss key findings from the last 5 years that reveal new insights into the mechanisms involved.
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