Journal
CELL STEM CELL
Volume 10, Issue 1, Pages 96-103Publisher
CELL PRESS
DOI: 10.1016/j.stem.2011.11.019
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Funding
- European Leukodystrophy Association (ELA)
- Research into Ageing
- UK Multiple Sclerosis Society
- National Multiple Sclerosis Society
- Burroughs-Wellcome Fund
- Harvard Stem Cell Institute
- British Consulate General Science and Innovation Network
- National Institutes of Health [1 DP2 OD004345-01]
- National Health and Medical Research Council of Australia
- Medical Research Council, UK
- Medical Research Council [G0800784B, G0800784] Funding Source: researchfish
- Rosetrees Trust [M144] Funding Source: researchfish
- MRC [G0800784] Funding Source: UKRI
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Remyelination is a regenerative process in the central nervous system (CNS) that produces new myelin sheaths from adult stem cells. The decline in remyelination that occurs with advancing age poses a significant barrier to therapy in the CNS, particularly for long-term demyelinating diseases such as multiple sclerosis (MS). Here we show that remyelination of experimentally induced demyelination is enhanced in old mice exposed to a youthful systemic milieu through heterochronic parabiosis. Restored remyelination in old animals involves recruitment to the repairing lesions of blood-derived monocytes from the young parabiotic partner, and preventing this recruitment partially inhibits rejuvenation of remyelination. These data suggest that enhanced remyelinating activity requires both youthful monocytes and other factors, and that remyelination-enhancing therapies targeting endogenous cells can be effective throughout life.
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