Journal
CELL STEM CELL
Volume 11, Issue 3, Pages 302-317Publisher
CELL PRESS
DOI: 10.1016/j.stem.2012.08.006
Keywords
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Categories
Funding
- Italian Leukemia and Lymphoma Association, section of Bologna (BolognaAIL)
- [DK092883]
- [DK060445]
- [AG036562]
- [CA126752]
- [CA125123]
- [AI007495]
- [NSC100-2811-B-002-163]
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Hematopoietic stem cells (HSCs) represent one of the first recognized somatic stem cell types. As such, nearly 200 genes have been examined for roles in HSC function in knockout mice. In this review, we compile the majority of these reports to provide a broad overview of the functional modules revealed by these genetic analyses and highlight some key regulatory pathways involved, including cell cycle control, Tgf-beta signaling, Pten/Akt signaling, Wnt signaling, and cytokine signaling. Finally, we propose recommendations for characterization of HSC function in knockout mice to facilitate cross-study comparisons that would generate a more cohesive picture of HSC biology.
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