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Asymmetric Stem Cell Division: Precision for Robustness

Journal

CELL STEM CELL
Volume 11, Issue 4, Pages 461-469

Publisher

CELL PRESS
DOI: 10.1016/j.stem.2012.09.003

Keywords

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Funding

  1. NIH [R01GM086481]
  2. John D. and Catherine T. MacArthur Foundation

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Asymmetric cell division (ACD) produces two daughter cells with distinct fates or characteristics. Many adult stem cells use ACD as a means of maintaining stem cell number and thus tissue homeostasis. Here, we review recent progress on ACD, discussing conservation between stem and non-stem cell systems, molecular mechanisms, and the biological meaning of ACD.

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