Journal
CELL STEM CELL
Volume 10, Issue 4, Pages 355-361Publisher
CELL PRESS
DOI: 10.1016/j.stem.2012.03.013
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Funding
- National Institutes of Health [HL087825, HL071589, HL110942]
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The lung is composed of numerous epithelial lineages that arise from the anterior foregut endoderm. This review discusses how insights into the signaling mechanisms that regulate lung endoderm specification and subsequent differentiation have recently been exploited to direct differentiation of hESCs/iPSCs into expandable lung progenitors.
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