Journal
CELL STEM CELL
Volume 10, Issue 6, Pages 666-677Publisher
CELL PRESS
DOI: 10.1016/j.stem.2012.05.003
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Funding
- Legacy Heritage Biomedical Science Partnership Program of the Israel Science Foundation [943/09]
- Centers of Excellence Legacy Heritage Biomedical Science Partnership [1801/10]
- Juvenile Diabetes Research Foundation [1-2011-555]
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The boundaries of embryonic stem cell (ESC) research have extended considerably in recent years in several important ways. Alongside a deeper understanding of the pluripotent state, ESCs have been successfully integrated into various fields, such as genomics, epigenetics, and disease modeling. Significant progress in cell fate control has pushed directed differentiation and tissue engineering further than ever before and promoted clinical trials. The geographical distribution of research activity has also expanded, especially for human ESCs. This review outlines these developments and future challenges that remain.
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