Journal
CELL STEM CELL
Volume 10, Issue 3, Pages 231-232Publisher
CELL PRESS
DOI: 10.1016/j.stem.2012.02.008
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- NCI NIH HHS [R01 CA151541-03, R01 CA151541] Funding Source: Medline
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Coordinated interactions between signaling networks govern the balance of cell fate decisions in human embryonic stem cells. In this issue, Singh et al. (2012) report that PI3K/Akt signaling switches Activin/Smad activity between pro-self-renewal and prodifferentiation by regulating ERK and GSK3 beta/beta-catenin signaling.
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