Journal
CELL STEM CELL
Volume 10, Issue 5, Pages 504-514Publisher
CELL PRESS
DOI: 10.1016/j.stem.2012.04.001
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Funding
- NIH [R01 AIR060868, P01 AG036695, R37 AG23806, RO1 AR056849]
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In 1961, the satellite cell was first identified when electron microscopic examination of skeletal muscle demonstrated a cell wedged between the plasma membrane of the muscle fiber and the basement membrane. In recent years it has been conclusively demonstrated that the satellite cell is the primary cellular source for muscle regeneration and is equipped with the potential to self renew, thus functioning as a bona fide skeletal muscle stem cell (MuSC). As we move past the 50th anniversary of the satellite cell, we take this opportunity to discuss the current state of the art and dissect the unknowns in the MuSC field.
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