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Bioresorbable polymeric stents: current status and future promise

Journal

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 14, Issue 4, Pages 299-312

Publisher

VSP BV
DOI: 10.1163/156856203321478838

Keywords

stent; bioresorbable polymer; drug delivery; gene therapy; in-stent restenosis

Funding

  1. NHLBI NIH HHS [R01 HL/DE 53225, F32HL010380] Funding Source: Medline
  2. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [F32HL010380, R01HL053225] Funding Source: NIH RePORTER

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Metal stents and, more recently, polymer-coated metal stents are used to stabilize dissections, eliminate vessel recoil, and guide remodeling after balloon angioplasty and other treatments for arterial disease. Bioresorbable polymeric stents are being developed to improve the biocompatibility and the drug reservoir capacity of metal stents, and to offer a transient alternative to the permanent metallic stent implant. Following a brief review of metal stent technology, the emerging class of expandable, bioresorbable polymeric stents is described, with emphasis on developments in the authors' laboratory.

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