Journal
CELL STEM CELL
Volume 9, Issue 3, Pages 187-192Publisher
CELL PRESS
DOI: 10.1016/j.stem.2011.08.005
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Funding
- Haematosys Program
- German Bundesministerium fur Bildung und Forschung (BMBF)
- EU
- Deutsche Forschungsgemeinschaft (DFG) [SFB 873]
- Dietmar Hopp Foundation
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The cell cycle regulators involved in maintaining the quiescence, and thereby the self-renewal capacity, of somatic stem cells have long been elusive. Two new Cell Stem Cell articles in this issue (Matsumoto et al., 2011; Zou et al., 2011) now show that the CDK inhibitor p57 is a crucial brake for cycling HSCs, and links self-renewal activity to cell cycle quiescence.
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