Journal
CELL STEM CELL
Volume 8, Issue 5, Pages 482-485Publisher
CELL PRESS
DOI: 10.1016/j.stem.2011.04.013
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Funding
- NCI NIH HHS [R01 CA129958, R01 CA154130, F32 CA142159, R01 CA116659] Funding Source: Medline
- NINDS NIH HHS [F32 NS058042, R01 NS054276] Funding Source: Medline
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Neural cancers display cellular hierarchies with self-renewing tumorigenic cancer stem cells (CSCs) at the apex. Instructive cues to maintain CSCs are generated by both intrinsic networks and the niche microenvironment. The CSC-microenvironment relationship is complex, as CSCs can modify their environment and extrinsic forces induce plasticity in the cellular hierarchy.
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