Journal
CELL STEM CELL
Volume 7, Issue 4, Pages 483-495Publisher
CELL PRESS
DOI: 10.1016/j.stem.2010.08.014
Keywords
-
Categories
Funding
- National Institute of Neurological Disorders and Stroke [R21NS05875-1, K08NS0044276]
- Child Neurology Society
- U.S. Army [DAMD170110754]
- NIH [P30HD024064]
- Farish foundation
- National Alliance for Research on Schizophrenia and Depression Young Investigator Award
- U.S. Department of Defense (DOD) [DAMD170110754] Funding Source: U.S. Department of Defense (DOD)
Ask authors/readers for more resources
In the adult hippocampus, neuroprogenitor cells in the subgranular zone (SGZ) of the dentate gyrus give rise to newborn neuroblasts. However, only a small subset of these cells integrates into the hippocampal circuitry as mature neurons at the end of a 4 week period. Here, we show that the majority of the newborn cells undergo death by apoptosis in the first 1 to 4 days of their life, during the transition from amplifying neuroprogenitors to neuroblasts. These apoptotic newborn cells are rapidly cleared out through phagocytosis by unchallenged microglia present in the adult SGZ niche. Phagocytosis by the microglia is efficient and undeterred by increased age or inflammatory challenge. Our results suggest that the main critical period of newborn cell survival occurs within a few days of birth and reveal a new role for microglia in maintaining the homeostasis of the baseline neurogenic cascade.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available