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MicroRNA Gene Regulatory Pathways in the Establishment and Maintenance of ESC Identity

Journal

CELL STEM CELL
Volume 7, Issue 1, Pages 31-35

Publisher

CELL PRESS
DOI: 10.1016/j.stem.2010.06.011

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Funding

  1. Children's Hospital Boston
  2. NIH-NIGMS [1R01GM086386-01A1]
  3. Harvard Stem Cell Institute
  4. Emerald Foundation

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Understanding the molecular foundations of embryonic stem cell (ESC) self-renewal and pluripotency will facilitate therapeutic exploitation of these remarkable cells. Here we discuss the emerging roles of microRNAs in the establishment and maintenance of ESC identity and summarize our current understanding of the mechanisms controlling microRNA expression and function in ESCs.

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