Journal
CELL STEM CELL
Volume 6, Issue 4, Pages 300-308Publisher
CELL PRESS
DOI: 10.1016/j.stem.2010.03.003
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Funding
- Juvenile Diabetes Research Foundation (JDRF)
- Larry L Hillblom Foundation (LLHF)
- Mead Foundation
- Snyder Foundation
- Stinehart Foundation
- Harry and Leona Helmsley Foundation
- JDRF
- LLHF
- California Institute of Regenerative Medicine
- U S National Institutes of Health
- Howard Hughes Medical Institute (HHMI)
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There is considerable excitement about harnessing the potential of human stem cells to replace pancreatic islets that are destroyed in type 1 diabetes mellitus. However, our current understanding of the mechanisms underlying pancreas and islet ontogeny has come largely from the powerful genetic, developmental, and embryological approaches available in nonhuman organisms. Successful islet reconstruction from human pluripotent cells will require greater attention to deconstructing human pancreas and islet developmental biology and consistent application of conditional genetics, lineage tracing, and cell purification to stem cell biology.
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