Journal
CELL STEM CELL
Volume 6, Issue 5, Pages 399-400Publisher
CELL PRESS
DOI: 10.1016/j.stem.2010.04.004
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Funding
- NCI NIH HHS [P01 CA093900, U54 CA163124] Funding Source: Medline
- NIAMS NIH HHS [P30 AR046024] Funding Source: Medline
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Whether the bone marrow microenvironment can contribute to development of blood borne cancers is controversial. In a recent issue of Nature, Raaijmakers et al. (2010) show that deletion of Dicerl specifically in osteoprogenitors not only impaired their differentiation but also resulted in disrupted blood formation and secondary leukemia.
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