Journal
CLINICAL & EXPERIMENTAL METASTASIS
Volume 20, Issue 1, Pages 59-68Publisher
SPRINGER
DOI: 10.1023/A:1022546620495
Keywords
EphA2; ephrin; metastasis; monoclonal antibody; oncogene; tyrosine kinase
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Cancer is a disease of aberrant signal transduction. The expression and function of intracellular signaling pathways are frequently subverted as cells progress towards a metastatic phenotype. In particular, tyrosine kinases initiate powerful signals that govern many different aspects of cell behavior. In Recent studies have demonstrated that the EphA2 receptor tyrosine kinase is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character. Herein, we provide an overview of our current understanding of EphA2, with emphasis upon the differential regulation of EphA2 expression and function. We also show that differential EphA2 expression and function may provide a unique opportunity for selective therapeutic targeting of EphA2 in metastatic disease.
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