Journal
CELL STEM CELL
Volume 4, Issue 5, Pages 387-397Publisher
CELL PRESS
DOI: 10.1016/j.stem.2009.04.011
Keywords
-
Categories
Funding
- ESTOOLS
- EuroSystem, European Union Sixth
- Seventh Framework Programme Integrated Projects
- Medical Research Council
- Leukaemia Research Foundation
- Yorkshire Cancer Research
- Swedish Foundation for Strategic Research
- Medical Research Council [G0700785, MC_U137973817] Funding Source: researchfish
- MRC [MC_U137973817, G0700785] Funding Source: UKRI
Ask authors/readers for more resources
Understanding cell-fate decisions in stem cell populations is a major goal of modern biology. Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. We discuss these properties with examples both from the hematopoietic and embryonic stem cell (ESC) systems. The nature of the stem cell substates and their relationship to commitment to differentiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available