Journal
CELL STEM CELL
Volume 2, Issue 4, Pages 313-319Publisher
CELL PRESS
DOI: 10.1016/j.stem.2008.03.002
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Funding
- Intramural NIH HHS [Z01 DE000380-24] Funding Source: Medline
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [Z01DE000380] Funding Source: NIH RePORTER
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The concept of mesenchymal stem cells has gained wide popularity. Despite the rapid growth of the field, uncertainties remain with respect to the defining characteristics of these cells, including their potency and self-renewal. These uncertainties are reflected in a growing tendency to question the very use of the term. This commentary revisits the experimental origin of the concept of the population(s) referred to as mesenchymal stem cells and the experimental framework required to assess their sternness and function.
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