Journal
CELL STEM CELL
Volume 2, Issue 6, Pages 538-549Publisher
CELL PRESS
DOI: 10.1016/j.stem.2008.05.002
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Funding
- NEI NIH HHS [R01 EY013475-07, R01 EY013475] Funding Source: Medline
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Neuronal degenerations in the retina are leading causes of blindness. Like most other areas of the CNS, the neurons of the mammalian retina are not replaced following degeneration. However, in nonmammalian vertebrates, endogenous repair processes restore neurons very efficiently, even after complete loss of the retina. We describe the phenomenon of retinal regeneration in nonmammalian vertebrates and attempts made in recent years to stimulate similar regenerative processes in the mammalian retina. In addition, we review the various strategies employed to replace lost neurons in the retina and the recent use of stem cell technologies to address problems of retinal repair.
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