Journal
CELL STEM CELL
Volume 3, Issue 4, Pages 369-381Publisher
CELL PRESS
DOI: 10.1016/j.stem.2008.09.001
Keywords
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Funding
- Guggenheim Foundation
- Canadian Stem Cell Network
- NSERC
- CIHR
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Stem cells have emerged as the starting material of choice for bioprocesses to produce cells and tissues to treat degenerative, genetic, and immunological disease. Translating the biological properties and potential of stem cells into therapies will require overcoming significant cell-manufacturing and regulatory challenges. Bioprocess engineering fundamentals, including bioreactor design and process control, need to be combined with cellular systems biology principles to guide the development of next-generation technologies capable of producing cell-based products in a safe, robust, and cost-effective manner. The step-wise implementation of these bioengineering strategies will enhance cell therapy product quality and safety, expediting clinical development.
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