Journal
CELL STEM CELL
Volume 3, Issue 4, Pages 382-388Publisher
CELL PRESS
DOI: 10.1016/j.stem.2008.09.015
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Funding
- Damon-Runyon Cancer Research Foundation
- National Institute of Health
- Harvard Stem Cell Institute
- HHMI
- JDRF
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Cells of adult mammals can be converted (reprogrammed) to new cells. In one approach, adult cells are converted to pluripotent stem cells, followed by differentiation to regenerate new cell types. Alternatively, adult cells may be directly converted into other mature cells or progenitors. We discuss and compare these two approaches with particular emphasis on the latter and its relevance for regenerative medicine.
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