Journal
CELL STEM CELL
Volume 3, Issue 5, Pages 484-492Publisher
CELL PRESS
DOI: 10.1016/j.stem.2008.10.006
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Funding
- Helen and Martin Kimmel Institute for Stem Cell Research at the Weizmann Institute
- Gabriella Rich Center for Transplantation Biology
- Legacy Heritage foundation
- Human Frontiers Science Program
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Physiological interactions between the nervous and immune systems with components of the local microenvironment are needed to maintain homeostasis throughout the body. Dynamic regulation of bone remodeling, hematopoietic stem cells, and their evolving niches via neurotransmitter signaling are part of the host defense and repair mechanisms. This crosstalk links activated leukocytes, neuronal, and stromal cells, which combine to directly and indirectly regulate hematopoietic stem cells. Together, interactions between diverse systems create a regulatory brain-bone-blood triad, contributing an additional dimension to the concept of the hematopoietic stem cell niche.
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