Journal
CELL STEM CELL
Volume 2, Issue 2, Pages 110-112Publisher
CELL PRESS
DOI: 10.1016/j.stem.2008.01.012
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Understanding the development and maintenance of dopamine neurons is essential to establish novel stem cell therapies and animal models of Parkinson's disease. A recent PLoS Biology report (Kittappa et al., 2007) reveals that Foxa2 regulates dopamine neuron generation and differentiation, and that aging foxa(2+/-) mice spontaneously develop Parkinsonism.
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