Journal
BIOLOGICAL PSYCHOLOGY
Volume 62, Issue 1, Pages 49-63Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0301-0511(02)00113-8
Keywords
auditory event-related potentials; development of a memory trace; frontal MMN generator; mismatch negativity; schizophrenic patients; temporal MMN generator
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The present study addresses the difference in activities of frontal and temporal mismatch negativity (MMN) generators between healthy controls and schizophrenic patients. Auditory MMNs were measured from 13 medicated schizophrenic patients in a post-acute phase and 12 healthy controls. The probabilities of the standard stimuli were, in different experimental blocks, 95, 90, 80 or 70%. The mean amplitude of the MMN recorded at Fz was significantly smaller in schizophrenic patients than healthy controls only in the conditions with high probability of standard stimuli, while that recorded at mastoid sites was not different in any condition. The present study suggested that schizophrenic patients might fail to cause involuntary attention switch to stimulus change reflected in the lowered MMN amplitude recorded at Fz; whereas the patients might index an adequate detection of the deviant event reflected by the similar amplitude of MMN recorded at mastoid sites. (C) 2002 Elsevier Science B.V. All rights reserved.
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