4.8 Article

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

Related references

Note: Only part of the references are listed.
Review Physiology

Lysosomal Acidification Mechanisms

Joseph A. Mindell

ANNUAL REVIEW OF PHYSIOLOGY, VOL 74 (2012)

Review Biochemistry & Molecular Biology

Mechanisms of Autophagosome Biogenesis

David C. Rubinsztein et al.

CURRENT BIOLOGY (2012)

Article Cell Biology

Dissecting the dynamic turnover of GFP-LC3 in the autolysosome

Hong-Min Ni et al.

AUTOPHAGY (2011)

Review Biochemistry & Molecular Biology

Autophagy: Renovation of Cells and Tissues

Noboru Mizushima et al.

Review Cell Biology

Autophagy in the Cellular Energetic Balance

Rajat Singh et al.

CELL METABOLISM (2011)

Review Cell Biology

The ESCRT Pathway

William M. Henne et al.

DEVELOPMENTAL CELL (2011)

Review Pharmacology & Pharmacy

Targeting the mTOR kinase domain: the second generation of mTOR inhibitors

Yan-Jie Zhang et al.

DRUG DISCOVERY TODAY (2011)

Review Chemistry, Medicinal

Recent advances in the discovery of small-molecule ATP competitive mTOR inhibitors: a patent review

Arie Zask et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2011)

Article Biochemistry & Molecular Biology

Fatty Acids Suppress Autophagic Turnover in β-Cells

Guy Las et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Relieving Autophagy and 4EBP1 from Rapamycin Resistance

Beat Nyfeler et al.

MOLECULAR AND CELLULAR BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest

Ian G. Ganley et al.

MOLECULAR CELL (2011)

Article Multidisciplinary Sciences

TFEB Links Autophagy to Lysosomal Biogenesis

Carmine Settembre et al.

SCIENCE (2011)

Article Cell Biology

Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview

Maryam Mehrpour et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2010)

Article Biotechnology & Applied Microbiology

Functional characterization of starvation-induced lysosomal activity in Saccharomyces cerevisiae

Jihee Yoon et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2010)

Article Cell Biology

The role of the Atg1/ULK1 complex in autophagy regulation

Noboru Mizushima

CURRENT OPINION IN CELL BIOLOGY (2010)

Article Cell Biology

Mammalian autophagy: core molecular machinery and signaling regulation

Zhifen Yang et al.

CURRENT OPINION IN CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders

Alessandro Fraldi et al.

EMBO JOURNAL (2010)

Article Cell Biology

Lysosomal accumulation of mTOR is enhanced by rapamycin

Yuki Ohsaki et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2010)

Article Multidisciplinary Sciences

Termination of autophagy and reformation of lysosomes regulated by mTOR

Li Yu et al.

NATURE (2010)

Review Biochemistry & Molecular Biology

Proteomics of the lysosome

Torben Luebke et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2009)

Review Oncology

The Applicability of mTOR Inhibition in Solid Tumors

I. R. H. M. Konings et al.

CURRENT CANCER DRUG TARGETS (2009)

Review Pharmacology & Pharmacy

Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies

V. Raja Solomon et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2009)

Article Biochemistry & Molecular Biology

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

Carson C. Thoreen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Review Cell Biology

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

Paul Saftig et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

Article Oncology

Evaluating Temsirolimus Activity in Multiple Tumors: A Review of Clinical Trials

Janet E. Dancey et al.

SEMINARS IN ONCOLOGY (2009)

Article Biochemistry & Molecular Biology

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

Morris E. Feldman et al.

PLOS BIOLOGY (2009)

Article Biochemistry & Molecular Biology

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

Jingxiang Huang et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Review Cell Biology

Lysosomes: fusion and function

J. Paul Luzio et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and α-synuclein

Sovan Sarkar et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Genetics & Heredity

Dynein mutations impair autophagic clearance of aggregate-prone proteins

B Ravikumar et al.

NATURE GENETICS (2005)

Article Cell Biology

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

M Komatsu et al.

JOURNAL OF CELL BIOLOGY (2005)

Article Cell Biology

Role for Rab7 in maturation of late autophagic vacuoles

S Jäger et al.

JOURNAL OF CELL SCIENCE (2004)

Article Multidisciplinary Sciences

The role of autophagy during the early neonatal starvation period

A Kuma et al.

NATURE (2004)

Article Cell Biology

Rab7 is required for the normal progression of the autophagic pathway in mammalian cells

MG Gutierrez et al.

JOURNAL OF CELL SCIENCE (2004)

Article Medicine, Research & Experimental

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

HB Zhang et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Review Cell Biology

Autophagosome formation in mammalian cells

N Mizushima et al.

CELL STRUCTURE AND FUNCTION (2002)

Article Cell Biology

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

N Mizushima et al.

JOURNAL OF CELL BIOLOGY (2001)