Journal
BREAST CANCER RESEARCH
Volume 5, Issue 3, Pages 136-139Publisher
BMC
DOI: 10.1186/bcr585
Keywords
hemodynamics; inflammatory breast cancer; vasculogenic mimicry; xenograft model
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We recently established a new human inflammatory breast cancer (IBC) xenograft (WIBC-9) originating from a patient with IBC. The original tumor and WIBC-9 revealed invasive ductal carcinoma with a hypervascular structure of solid nests and marked lymphatic permeation in the overlying dermis. In the central part of the solid nests, vasculogenic mimicry, which showed an absence of endothelial cells, was observed. Comparison of WIBC-9 with an established non-IBC xenograft (MC-5), using time-course dynamic micro-magnetic resonance angiography analysis ( with a newly developed intravascular macromolecular contrast agent for magnetic resonance imaging) demonstrated that the WIBC-9 tumor had blood flow and a vascular mimicry - angiogenesis junction.
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