Journal
BIOLOGY OF THE NEONATE
Volume 83, Issue 3, Pages 166-170Publisher
KARGER
DOI: 10.1159/000068924
Keywords
intracerebral hemorrhage; chorioamnionitis; fetal inflammation; proinflammatory cytokines
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The objective of this study was to investigate in a prospectie study whether histological chorioamnionitis (ChA) is a risk factor predisposing for intracerebral hemorrhage (ICH), and whether ICH is associated with a systemic fetal inflammation in preterm neonates with a gestational age <32 weeks. 106 neonates were studied; 20 (18.9%) suffered from ICH. ChA occurred significantly more often in neonates with ICH compared to neonates without ICH (70.0 vs. 36.0%, p = 0.006). Neonates with ICH had significantly higher median levels of proinflammatory cytokines (IL-1β, IL-6 and IL-8) compared to neonates without ICH (p < 0.001 for all comparisons). We conclude that the development of ICH in preterm infants is associated with both ChA and high levels of proinflammatory cytokines at birth. Copyright (C) 2003 S. Karger AG, Basel.
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