Journal
CELL RESEARCH
Volume 23, Issue 4, Pages 463-464Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/cr.2013.9
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Protein homeostasis in higher eukaryotes is balanced by a dynamic network of adaptive mechanisms, including the unfolded protein response (UPR) and autophagy. In a paper recently published in Cell Research, Zhu and co-workers uncover a novel biological function of the unspliced form of the UPR transcription factor XBP1 in the modulation of autophagy through the control of FoxO1 turnover.
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