Journal
CELL RESEARCH
Volume 22, Issue 8, Pages 1215-1217Publisher
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2012.62
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Initial studies linking Sirtuins to longevity in yeast initiated what is now a rich vein of aging research that is full of promise and fraught with controversy. Missing was a demonstration that enhanced Sirtuin expression extends lifespan in mammals. Now Kanfi et al. provide the evidence but with an interesting plot twist - the lesser known SIRT6 is the longevity factor.
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