Journal
CELL RESEARCH
Volume 23, Issue 1, Pages 81-91Publisher
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2012.182
Keywords
small molecules; stem cells; self-renewal; differentiation
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Funding
- NICHD NIH HHS [R01 HD064610] Funding Source: Medline
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Stem cells, including both pluripotent stem cells and multipotent somatic stem cells, hold great potential for interrogating the mechanisms of tissue development, homeostasis and pathology, and for treating numerous devastating diseases. Establishment of in vitro platforms to faithfully maintain and precisely manipulate stem cell fates is essential to understand the basic mechanisms of stem cell biology, and to translate stem cells into regenerative medicine. Chemical approaches have recently provided a number of small molecules that can be used to control cell self-renewal, lineage differentiation, reprogramming and regeneration. These chemical modulators have been proven to be versatile tools for probing stem cell biology and manipulating cell fates toward desired outcomes. Ultimately, this strategy is promising to be a new frontier for drug development aimed at endogenous stem cell modulation.
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