Journal
CELL RESEARCH
Volume 22, Issue 7, Pages 1092-1094Publisher
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2012.42
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- Intramural NIH HHS Funding Source: Medline
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LRRK2 was recently identified as a major susceptibility gene for Crohn's disease (CD) by genome-wide association studies (GWAS). LRRK2 deficiency in mice confers enhanced susceptibility to experimental colitis. In this research highlight, we discuss the current understanding of LRRK2 in the context of colitis, and postulate the future directions.
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