Journal
CELL RESEARCH
Volume 21, Issue 1, Pages 103-115Publisher
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2010.178
Keywords
reactive oxygen species (ROS); NF-kappa B; oxidative stress; antioxidants
Categories
Funding
- National Institutes of Health, National Cancer Institute, Center for Cancer Research
- NATIONAL CANCER INSTITUTE [ZIASC010376, ZIABC010783] Funding Source: NIH RePORTER
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NF-kappa B proteins are a family of transcription factors that are of central importance in inflammation and immunity. NF-kappa B also plays important roles in other processes, including development, cell growth and survival, and proliferation, and is involved in many pathological conditions. Reactive Oxygen Species (ROS) are created by a variety of cellular processes as part of cellular signaling events. While certain NF-kappa B-regulated genes play a major role in regulating the amount of ROS in the cell, ROS have various inhibitory or stimulatory roles in NF-kappa B signaling. Here we review the regulation of ROS levels by NF-kappa B targets and various ways in which ROS have been proposed to impact NF-kappa B signaling pathways.
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