Journal
CELL RESEARCH
Volume 21, Issue 1, Pages 183-195Publisher
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2010.171
Keywords
NF-kappa B; crystal structure; TRAF; NEMO
Categories
Funding
- NIH [AI045937, AI050872, AI079260]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI050872, R01AI045937, R01AI079260, R01AI050872] Funding Source: NIH RePORTER
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NF-kappa Bs are a family of transcription factors that control a number of essential cellular functions including immune responses, cell proliferation and antiapoptosis. NF-kappa B activities are tightly regulated through upstream signaling molecules and downstream feedback loops. In this review, structural discoveries in the NF-kappa B pathway are presented. With the structure information, the following questions may be addressed: (1) How do NF-kappa Bs activate their target genes? (2) How do I kappa Bs inhibit NF-kappa B activities in the steady state? (3) How do upstream signaling molecules activate the NF-kappa B pathway? and (4) How do the feedback loops shut down the NF-kappa B pathway to avoid constitutive NF-kappa B activation?
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