Journal
CELL RESEARCH
Volume 21, Issue 1, Pages 55-70Publisher
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2010.182
Keywords
CARMA1; CARMA2; CARMA3; CARD9; Bcl10; NF-kappa B; IKK; NEMO
Categories
Funding
- National Institutes of Health [RO1GM065899, RO1GM079451, RO1AI050848]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI050848] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM079451, R01GM065899] Funding Source: NIH RePORTER
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The NF-kappa B family of transcription factors plays a crucial role in cell activation, survival and proliferation. Its aberrant activity results in cancer, immunodeficiency or autoimmune disorders. Over the past two decades, tremendous progress has been made in our understanding of the signals that regulate NF-kappa B activation, especially how scaffold proteins link different receptors to the NF-kappa B-activating complex, the I kappa B kinase complex. The growing number of these scaffolds underscores the complexity of the signaling networks in different cell types. In this review, we discuss the role of scaffold molecules in signaling cascades induced by stimulation of antigen receptors, G-protein-coupled receptors and C-type Lectin receptors, resulting in NF-kappa B activation. Especially, we focus on the family of Caspase recruitment domain (CARD)-containing proteins known as CARMA and their function in activation of NF-kappa B, as well as the link of these scaffolds to the development of various neoplastic diseases through regulation of NF-kappa B.
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