Journal
CELL RESEARCH
Volume 19, Issue 5, Pages 532-545Publisher
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2009.41
Keywords
Wnt; cytoskeleton; cilia; cell adhesion; Rho
Categories
Funding
- National Institutes of Health/National Cancer Institute
- National Science Council of Taiwan
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Wnt/beta-catenin regulates cellular functions related to tumor initiation and progression, cell proliferation, differentiation, survival, and adhesion. beta-Catenin-independent Wnt pathways have been proposed to regulate cell polarity and migration, including metastasis. In this review, we discuss the possible roles of both beta-catenin-dependent and -independent signaling pathways in tumor progression, with an emphasis on their regulation of Rho-family GTPases, cytoskeletal remodeling, and relationships with cell-cell adhesion and cilia/ciliogenesis.
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