Journal
JOURNAL OF APPLIED PHYCOLOGY
Volume 15, Issue 6, Pages 507-511Publisher
SPRINGER
DOI: 10.1023/B:JAPH.0000004344.45697.0f
Keywords
phlorotannins; Sargassum kjellmanianum; liver; peroxidation
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The inhibitory effects of high molecular weight phlorotannins (HMP) from Sargassum kjellmanianum on mouse liver lipid peroxidation were investigated by spectrophotometric methods. The content of malondialdehyde (MDA) in liver samples was measured by TBA (thiobarbituric acid) assay. It showed that HMP significantly inhibited the generation of MDA in vivo and in situations induced by CCl4 and Fe2+-Vc ( ascorbic acid), and significantly decreased membrane swelling of mouse liver mitochondria, compared with controls ( p < 0.01). HMP were found to have strong anti-oxidative activity in inhibiting mouse liver lipid peroxidation.
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