Journal
AUTOIMMUNITY
Volume 36, Issue 8, Pages 457-461Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08916930310001605855
Keywords
interferon; interferon-stimulated genes; interferon receptor; autoimmune disease
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Type I Interferons (IFN) induce the expression of IFN-stimulated genes (ISG). The products of some of these genes have direct antiviral effects, others are involved in immunoregulation or modulate signaling pathways and gene expression, and others yet are mediators of cell growth and death. Their role in autoimmune diseases has been found to be both beneficial and detrimental.
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