Journal
CELL RESEARCH
Volume 19, Issue 1, Pages 116-127Publisher
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/cr.2008.326
Keywords
angiogenesis; BMP; Marfan syndrome; Smad; pre-eclampsia; pulmonary hypertension; TGF-beta
Categories
Funding
- Centre for Biomedical Genetics
- Ludwig Institute for Cancer Research
- Dutch Cancer Society [UL-2005-3371]
- EU FP6
Ask authors/readers for more resources
Transforming growth factor (TGF)-beta family members are multifunctional cytokines that elicit their effects on cells, including endothelial and mural cells, via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. Knock-out mouse models for TGF-beta family signaling pathway components have revealed their critical importance in proper yolk sac angiogenesis. Genetic studies in humans have linked mutations in these signaling components to specific cardiovascular syndromes such as hereditary hemorrhagic telangiectasia, primary pulmonary hypertension and Marfan syndrome. In this review, we present recent advances in our understanding of the role of TGF-beta receptor signaling in vascular biology and disease, and discuss how this may be applied therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available