4.4 Article

Dynamics of annual influenza A epidemics with immuno-selection

Journal

JOURNAL OF MATHEMATICAL BIOLOGY
Volume 46, Issue 6, Pages 504-536

Publisher

SPRINGER HEIDELBERG
DOI: 10.1007/s00285-002-0186-2

Keywords

infectious disease; influenza drift; cross-immunity; seasonal epidemics; iterated map

Funding

  1. NIGMS NIH HHS [1 R01 GM607929] Funding Source: Medline

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The persistence of Influenza A in the human population relies on continual changes in the viral surface antigens allowing the virus to reinfect the same hosts every few years. The epidemiology of such a drifting virus is modeled by a discrete season-to-season map. During the epidemic season only one strain is present and its transmission dynamics follows a standard epidemic model. After the season, cross-immunity to next year's virus is determined from the proportion of hosts that were infected during the season. A partial analysis of this map shows the existence of oscillations where epidemics occur at regular or irregular intervals.

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