Journal
CELL PROLIFERATION
Volume 48, Issue 1, Pages 17-28Publisher
WILEY
DOI: 10.1111/cpr.12155
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Funding
- Key Projects of the National Science and Technology Pillar Program [2012BAI30B02]
- National Natural Science Foundation of China [U1170302, 81160543, 81260628, 81303270, 81172374]
- West China Hospital-Chengdu Science and Technology Department Translational Medicine Innovation Foundation [ZH13039]
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Ubiquitously distributed in different plant species, plant lectins are highly diverse carbohydrate-binding proteins of non-immune origin. They have interesting pharmacological activities and currently are of great interest to thousands of people working on biomedical research in cancer-related problems. It has been widely accepted that plant lectins affect both apoptosis and autophagy by modulating representative signalling pathways involved in Bcl-2 family, caspase family, p53, PI3K/Akt, ERK, BNIP3, Ras-Raf and ATG families, in cancer. Plant lectins may have a role as potential new anti-tumour agents in cancer drug discovery. Thus, here we summarize these findings on pathway- involved plant lectins, to provide a comprehensive perspective for further elucidating their potential role as novel anti-cancer drugs, with respect to both apoptosis and autophagy in cancer pathogenesis, and future therapy.
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