Journal
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
Volume 15, Issue 3, Pages 151-154Publisher
KARGER
DOI: 10.1159/000068480
Keywords
Alzheimer's disease; apolipoprotein E; H63D mutation; hemochromatosis; HFE gene
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The H63D mutation in the hemochromatosis gene (HFE) has recently been considered as a risk factor in Alzheimer's disease (AD) with advancing age at onset of the disease, independently of the apolipoprotein E (ApoE) epsilon4 allele effect. We examined the distribution of the H63D mutation and ApoE genotypes as a function of age at AD onset in 328 patients with sporadic AD. Our data show that the mutant H63D allele potentially interacts with the ApoE F,4 allele to significantly reduce age at onset of AD compared to ApoE epsilon4 carriers alone, but has no effect on age at onset in ApoE epsilon4 non-carriers. Copyright (C) 2003 S. Karger AG, Basel.
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