Journal
CELL METABOLISM
Volume 29, Issue 1, Pages 221-+Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2018.08.011
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Funding
- Intramural Research Program of the National Institute on Aging, NIH
- NATIONAL INSTITUTE ON AGING [ZIAAG000371, ZIAAG000363, ZIAAG000368] Funding Source: NIH RePORTER
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The importance of dietary composition and feeding patterns in aging remains largely unexplored, but was implicated recently in two prominent nonhuman primate studies. Here, we directly compare in mice the two diets used in the primate studies focusing on three paradigms: ad libitum (AL), 30% calorie restriction (CR), and single-meal feeding (MF), which accounts for differences in energy density and caloric intake consumed by the AL mice. MF and CR regimes enhanced longevity regardless of diet composition, which alone had no significant impact within feeding regimens. Like CR animals, MF mice ate quickly, imposing periods of extended daily fasting on themselves that produced significant improvements in morbidity and mortality compared with AL. These health and survival benefits conferred by periods of extended daily fasting, independent of dietary composition, have major implications for human health and clinical applicability.
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