Journal
CYTOTHERAPY
Volume 5, Issue 5, Pages 362-369Publisher
ELSEVIER SCI LTD
DOI: 10.1080/14653240310003026
Keywords
adipose tissue; stem cell; multipotent; tissue engineering
Categories
Funding
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R29AR043876, R56AR049249, R01AR049249, R01AR048182] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG015768] Funding Source: NIH RePORTER
- NIAMS NIH HHS [AR49249, AR43876, AR48182] Funding Source: Medline
- NIA NIH HHS [AG15768] Funding Source: Medline
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Adipose tissue is an abundant, accessible, and replenisbable source of adult stem cells that can be isolated from liposuction Waste tissue by collagenase digestion and differential centrifugation. These adipose-derived adult stem (ADAS) cells are multipotent, differentiating along the adipocyte, chondrocyte, myocyte, neuronal, and osteoblast lineages, and can serve in other capacities, such as providing hematopoietic support and gene transfer. ADAS cells have potential applications for the repair and regeneration of acute and chronically damaged tissues. Additional pre-clinical safety and efficacy studies will be needed before the promise of these cells can be fully realized.
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