Journal
JOURNAL OF VISION
Volume 3, Issue 2, Pages 171-182Publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
DOI: 10.1167/3.2.5
Keywords
multifocal; VEP; chromatic axes; color
Categories
Funding
- NEI NIH HHS [EY12576, P30 EY012576] Funding Source: Medline
- NIA NIH HHS [AG1869-01, R01 AG004058, AG04058, R37 AG004058, R37 AG004058-20] Funding Source: Medline
- NATIONAL EYE INSTITUTE [P30EY012576] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R37AG004058, R23AG004058, R01AG004058] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The chromatic pattern-onset VEP has been used successfully as a sensitive and objective technique to determine congenital and acquired color vision deficiency. It also has been applied to characterize development, maturation and aging of the chromatic visual pathways. Here we determine the topographic components of the full-field VEP using the multifocal technique. Recordings were made with the VERIS(TM) system that extracts topographic VEPs using a pseudorandom stimulus sequence. Chromatic pattern stimuli were presented in an onset-offset temporal sequence, with colors modulated along different axes in the MBDKL color space. Additional experiments were conducted to verify the Scone axis for each observer and that our chromatic stimuli were close to isoluminant at different field locations. Our data show reliable and robust chromatic onset VEP responses for multiple retinal areas that conform to pattern-onset full-field VEP waveform characteristics. For stimuli with chromatic contributions, pattern-onsets produced reliable and consistent waveforms whereas for stimuli with large luminance contributions pattern-reversal stimuli were superior. Our method for recording chromatic multifocal pattern-onset VEPs holds promise for clinical application to detect and monitor early retinal and optic nerve changes related to aging and disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available