Journal
CELL METABOLISM
Volume 19, Issue 1, Pages 49-57Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2013.11.020
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Funding
- Department of Health and Human Services Health Resources and Services Administration [1C76HF15069-01-00, 1C76HF19619-01-00]
- National Institutes of Health [P50 NS006833]
- National Institute of Neurologic Disorders and Stroke [P30 NS048056]
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Aerobic glycolysis (AG; i.e., nonoxidative metabolism of glucose despite the presence of abundant oxygen) accounts for 10%-12% of glucose used by the adult human brain. AG varies regionally in the resting state. Brain AG may support synaptic growth and remodeling; however, data supporting this hypothesis are sparse. Here, we report on investigations on the role of AG in the human brain. Meta-analysis of prior brain glucose and oxygen metabolism studies demonstrates that AG increases during childhood, precisely when synaptic growth rates are highest. In resting adult humans, AG correlates with the persistence of gene expression typical of infancy (transcriptional neoteny). In brain regions with the highest AG, we find increased gene expression related to synapse formation and growth. In contrast, regions high in oxidative glucose metabolism express genes related to mitochondria and synaptic transmission. Our results suggest that brain AG supports developmental processes, particularly those required for synapse formation and growth.
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