Journal
CELL METABOLISM
Volume 19, Issue 2, Pages 181-192Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2013.12.008
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Funding
- National Institute on Aging
- Glenn Foundation for Medical Research
- NIH/NIA [AG20642, AG025135, AG034906]
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Fasting has been practiced for millennia, but, only recently, studies have shed light on its role in adaptive cellular responses that reduce oxidative damage and inflammation, optimize energy metabolism, and bolster cellular protection. In lower eukaryotes, chronic fasting extends longevity, in part, by reprogramming metabolic and stress resistance pathways. In rodents intermittent or periodic fasting protects against diabetes, cancers, heart disease, and neurodegeneration, while in humans it helps reduce obesity, hypertension, asthma, and rheumatoid arthritis. Thus, fasting has the potential to delay aging and help prevent and treat diseases while minimizing the side effects caused by chronic dietary interventions.
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