Journal
CELL METABOLISM
Volume 20, Issue 6, Pages 926-927Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2014.11.015
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Ex vivo experiments have strangely shown that inhibition or stimulation of NAD metabolism can be neuroprotective. In this issue of Cell Metabolism, Brown et al. (2014) demonstrate that cochlear NAD is diminished by deafening noise but protected by nicotinamide riboside or WldS mutation. Hearing protection by nicotinamide riboside depends on Sirt3.
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