Journal
CELL METABOLISM
Volume 20, Issue 2, Pages 197-199Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2014.07.013
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- NIDDK NIH HHS [P01 DK049210] Funding Source: Medline
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Metformin is the most widely prescribed drug to lower glucose in type II diabetics, yet its mechanism of action remains controversial. A new study reveals that metformin inhibits mitochondrial glycerol-3-phosphate dehydrogenase, triggering reduction of the cytosolic NADH/NAD(+) pool and impaired utilization of redox-dependent substrates for gluconeogenesis (Madiraju et al., 2014).
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